Specialized Organic Synthesis Hub

Pharmaceutical Intermediates & Building Blocks

Empowering global innovative drug discovery and CDMO pipelines with high-purity malonic esters, heterocycles, targeted inhibitors, and scalable custom synthesis.

Core Building Blocks & Intermediates Advanced Targeted Intermediates Specialty Organocatalysts Custom Synthesis & CDMO

Core Building Blocks & Malonic Derivatives

High-Purity Standards • In-Stock Commercial Capacity
Flagship Precursor
Diethyl Malonate High-Purity Synthesis

High-Purity GC Analytics

Verified purity ≥ 99.5% with ultra-low moisture

Diethyl Malonate

CAS: 105-53-3 Purity: ≥ 99.5% (GC) Packaging: 200kg Galvanized Drum

Essential organic building block widely deployed in the synthesis of barbiturates, B-complex vitamins, anti-inflammatory compounds, and novel heterocyclic API frameworks.

Request Sample & Batch COA
Moisture (KF): ≤ 0.05%
Acidity: ≤ 0.02%
Appearance: Clear Colorless Liquid
Capacity: 10,000 MT / Year

Dimethyl Malonate

CAS: 108-59-8

Essential C4 diester reagent optimized for targeted drug synthesis with ultra-low moisture parameters.

Purity (GC): ≥ 99.5%
Packaging: 200kg Iron Drum

4,6-Dihydroxypyrimidine

CAS: 119-41-5

Crucial pyrimidine heterocyclic intermediate extensively applied in antineoplastic and vitamin pre-cursor synthesis.

Purity (HPLC): ≥ 99.0%
Packaging: 25kg Fiber Drum

Triethyl Orthoformate

CAS: 122-51-0

Versatile orthoester reagent used in pharmaceutical heterocycle formation and advanced organic chemistry.

Purity (GC): ≥ 99.0%
Packaging: 180kg Plastic Drum

Dimethyl Methylmalonate

CAS: 609-02-9

Substituted malonate derivative designed for specialized medicinal chemistry scaffold development.

Purity (GC): ≥ 99.0%
Packaging: 200kg Drum

Diethyl Methylmalonate

CAS: 609-03-5

High-purity alkylated malonate ester for pharmaceutical synthesis and fine organic transformations.

Purity (GC): ≥ 99.0%
Packaging: 200kg Drum

6-Amino-1,3-dimethyluracil

CAS: 6642-31-5

Uracil heterocyclic intermediate involved in bronchodilator and xanthine-derived pharmaceutical synthesis.

Purity: ≥ 98.5%
Packaging: 25kg Bag/Drum

Advanced Targeted Intermediates & Discovery Series

High-Barrier Synthesis • Custom Impurity Control

6-Amino-1,3-dimethyl-5-isonitrosouracil

CAS: 39946-13-5

High-barrier antiviral and targeted intermediate requiring precise nitrosation and cyclization reaction control.

Purity (HPLC): ≥ 98.0%
Packaging: 25kg Fiber Drum

ASK1 Inhibitor Intermediates

Targeted Pipeline Candidates

Specialized chemical building blocks tailored for apoptosis signal-regulating kinase 1 targeted therapeutic research.

Purity: ≥ 98.5% (HPLC)
Scale: Gram to Kilogram

Small Molecule Discovery Candidates (CS Series)

Custom Pipeline Intermediates

Advanced custom building blocks (including CS944X, CS3158, CS410) for preclinical small molecule drug pipelines.

Structure: Strict Confidentiality
Lead Time: Custom Synthesis

Specialty Organocatalysts & Reagents

Strong Non-Nucleophilic Bases • Anhydrous Reactions

DBU (1,8-Diazabicyclo[5.4.0]undec-7-ene)

CAS: 6674-22-2

Strong amidine base catalyst applied in non-aqueous coupling, dehydrohalogenation, and condensation reactions.

Purity (GC): ≥ 99.0%
Packaging: 200kg Steel Drum

DBN (1,5-Diazabicyclo[4.3.0]non-5-ene)

CAS: 3001-72-7

Specialized bicyclic amidine base catalyst for sensitive organic transformations and elimination steps.

Purity (GC): ≥ 98.5%
Packaging: 200kg Drum

1,1,3,3-Tetramethylguanidine (TMG)

CAS: 80-70-6

Strongly basic guanidine organic catalyst widely utilized in alkylation and pharmaceutical chemical synthesis.

Purity (GC): ≥ 99.0%
Packaging: 190kg Drum

Custom Synthesis & Pilot Scale-Up Capabilities

Milligrams to Metric Tons • Full Analytical Profiling

Tailored Route Scouting & Controlled Scale-Up

Beyond our catalog building blocks, Hongtai Pharma provides full-spectrum custom synthesis and scale-up services for global drug discovery teams. Governed by strict telemetry control and double-verification analytics, we ensure seamless technology transfer from R&D to pilot facilities.

IP Protection

Strict non-disclosure protocols securing your structural assets.

Full Analytics

Comprehensive NMR, HPLC, GC-MS, and KF testing data.

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Hongtai Pharma R&D and Synthesis Workshop

Advanced Synthesis Workshop

Multi-purpose reactors supporting nitration, cyclization, and esterification.